Oligo Synthesis &
Genomics Solutions
We supply Integrated DNA Technologies (IDT) custom oligonucleotides, qPCR probes, gene fragments, CRISPR reagents, NGS products, and bulk synthesis services for researchers across Malaysia.
- Pricing and lead times are subject to Apical Scientific’s local quotation process within Malaysia.
- Products are intended for Research Use Only (RUO) and are not for use in diagnostic procedures.
- Unless otherwise agreed in writing, IDT does not intend for these products to be used in clinical applications and does not warrant their fitness or suitability for any clinical diagnostic use.
- The purchaser is solely responsible for all decisions regarding the use of these products, including any associated regulatory or legal obligations.
Design
Use IDT’s free SciTools to design your oligo, primer, or assay before placing any order.
Choose Your Ordering Path
Order standard oligo and catalogue products directly online, or submit custom, modified, or large-scale synthesis requirements to us.
Confirmation & Processing
Receive order confirmation for direct online purchases, or confirm a local quotation with our consultation for custom projects.
Manufacturing & Delivery
IDT manufactures and ships products to us, while we coordinate, support, and deliver directly to you.
1. Custom DNA Oligos & Primers
Custom single-stranded or duplex DNA oligos for PCR, sequencing, mutagenesis, and NGS applications. IDT’s core oligo service includes ESI-MS quality control and multiple synthesis scale options, from 25 nmol for routine primers up to 10 µmol for high-demand workflows.
- PCR and Sanger sequencing primers
- qPCR probe/primer workflows
- Indexed adapters and fusion primers for NGS
- Site-directed mutagenesis
- CRISPR HDR donor templates (Ultramer DNA Oligos up to 200 bases)
| Synthesis scales | 25 nmol, 100 nmol, 250 nmol, 1 µmol, 2 µmol, 5 µmol, 10 µmol |
| Standard purification | Desalting (included); PAGE and HPLC available |
| Length range | 10–100 bases (scale-dependent); Ultramer up to 200 bases |
| QC method | ESI-MS + UV spectrophotometry on all oligos |
| Delivery | Dry or resuspended (IDTE buffer, pH 8.0) |
| Yield guarantee | From 10 nmol (25 nmol scale) to 2 µmol (10 µmol scale) |
| Turnaround | 3 to 5 working days |
Ultramer DNA Oligos
Up to 200 bases for long-oligo applications requiring extended synthesis capability.
TruGrade DNA Oligos
For multiplex NGS workflows with minimised cross-contamination between indexed oligos.
2. Custom RNA Oligos
Custom single-stranded and duplex RNA oligos for CRISPR guide RNA workflows, RNAi, aptamers, template switching, and RNA structural studies. Ultramer RNA Oligos extend synthesis to 120 bases for demanding applications.
- CRISPR guide RNAs and sgRNA-related workflows
- RNAi duplexes and RNA silencing
- NGS template switching oligos
- microRNA and aptamer workflows
- RNA controls for qPCR
| Synthesis scales | 100 nmol, 250 nmol, 1 µmol, 2 µmol, 5 µmol, 10 µmol |
| Purification | Desalting standard; RNase-free HPLC available |
| Modifications supported | Unmodified RNA, 2′-O-methyl RNA, chimeric DNA/RNA |
| Length range | Standard RNA: 5–60 bases; Ultramer RNA: up to 120 bases |
| QC method | ESI-MS + UV spectrophotometry |
| Delivery | Single-stranded: dry; Duplexed: annealed, dry |
| Yield guarantee | Ultramer RNA guaranteed at 4, 20, or 80 nmol |
| Turnaround | 3 to 4 weeks |
3. Modified Oligos & Fluorescent Labels
Oligos with chemical modifications for detection, capture, labelling, and specialised assay design. IDT offers more than 1,000 catalogue modifications including fluorophores, quenchers, biotin, phosphorylation, spacers, and backbone chemistry. Off-catalogue modifications are also available via consultation.
- Fluorescent qPCR and dPCR probes
- FRET, molecular beacon, and quenching workflows
- Biotin or amine capture and immobilisation
- Phosphorylated oligos for cloning and ligation
- Nuclease-resistant phosphorothioate oligos
| Modification categories | Fluorophores, dark quenchers, modified bases, phosphorylation, spacers, click chemistry groups, phosphorothioate bonds, linkers |
| Minimum scale (modified) | Typically 100 nmol; off-catalogue may require higher |
| Catalogue modifications | Selectable online in IDT oligo entry form |
| Purification | HPLC required for dye-labelled oligos; PAGE for long unmodified |
| Turnaround | 1 to 2 weeks — off-catalogue modifications may increase lead time |
4. qPCR Probes & Primer Assays
Custom PrimeTime qPCR probes and primer assays for gene expression, digital PCR, and multiplex detection. All probes are HPLC-purified and quality controlled by ESI-MS, with a choice of IDT’s license-free fluorophore and quencher combinations.
- qPCR gene expression assays
- Digital PCR (dPCR)
- Multiplex qPCR probe panels
- Custom primer/probe assay design
- Genotyping and target detection workflows
| Probe types | PrimeTime qPCR Probes, Affinity Plus, PrimeTime LNA, Molecular Beacons, MGB Eclipse, GMP Primers & Probes |
| Dyes (license-free) | FAM, Yakima Yellow, SUN, HEX, Cy3, Texas Red-X, Cy5 |
| Quenchers | Iowa Black FQ/RQ, ZEN (internal), TAO (internal) — double-quenched options available |
| Probe lengths | Standard: 15–35 bases |
| Purification | HPLC-purified standard for all PrimeTime probes |
| QC | ESI-MS on all probes |
| Scales | 100 nmol, 250 nmol, 1 µmol; Mini/Eco: 0.5 and 2.5 nmol |
| Turnaround | 2 to 3 weeks |
5. Gene Synthesis & Gene Fragments
Synthetic double-stranded DNA fragments and cloned genes for cloning, DNA assembly, CRISPR HDR templates, and synthetic biology. IDT offers multiple product tiers from short linear fragments to full cloned genes up to 5,000+ bp.
- Cloning and DNA assembly
- Gene construction and construct optimisation
- CRISPR HDR donor templates
- Screening workflows
- In vitro transcription templates
- Synthetic biology and protein expression
| Product | Format | Size Range | Turnaround | Yield |
|---|---|---|---|---|
| eBlocks | Linear dsDNA | 300–1,500 bp | 1–2 weeks | 200 ng |
| gBlocks | Linear dsDNA | 125–3,000 bp | 2–3 weeks | 250–1,000 ng |
| gBlocks HiFi | Linear dsDNA | 1,000–3,000 bp | 3–4 weeks | 1,000 ng |
| Gene Synthesis | Cloned in plasmid | 25–5,000+ bp | 3–5 weeks | 3–100 µg |
| Rapid Genes | Cloned in plasmid | 125–2,000 bp | 3–4 weeks | 1 µg |
⚠ Important — Biosecurity & Sequence Acceptance
- Sequence acceptance is subject to IDT’s review, including biosecurity screening.
- A biosecurity self-declaration is mandatory before any order can be processed.
- Sequences with very low or high GC content, long homopolymers, repeats, or hairpins may require design adjustments or may not be accepted.
6. CRISPR Alt-R Reagents & Guide RNAs
IDT’s Alt-R CRISPR portfolio provides guide RNAs, Cas proteins, HDR donor templates, and controls for Cas9 and Cas12a editing workflows. Predesigned guides are available for human, mouse, rat, zebrafish, and nematode genes; custom guides are available for any species or target.
- Gene knockout
- Gene knock-in and HDR editing
- SNP, insertion, deletion, and tag insertion workflows
- CRISPR screening and guide RNA libraries
- Editing validation and on/off-target analysis
| Cas9 guide formats | crRNA (35–36 nt), tracrRNA (67 nt), sgRNA (99–100 nt) |
| Cas12a guide formats | crRNA (40–44 nt) |
| Cas proteins | Cas9, HiFi Cas9, nickases (H840A, D10A); Cas12a, Cas12a Ultra |
| PAM sequences | NGG (Cas9), TTTV (Cas12a), TTTN (Cas12a Ultra) |
| Purification | Standard desalt or HPLC (HPLC recommended for translational use) |
| Delivery formats | Tubes, plates, or RNP-ready format |
| Species coverage | Human, mouse, rat, zebrafish, nematode (predesigned); any species (custom) |
7. Next Generation Sequencing (xGen NGS)
IDT’s xGen NGS portfolio includes hybridization capture panels, NGS library preparation reagents, adapters, and amplicon sequencing tools for targeted sequencing, whole exome sequencing, and custom panel design. Predesigned and custom xGen hybrid capture panels are available.
- Targeted DNA sequencing
- Whole exome sequencing
- Custom hybrid capture panels for cancer, inherited disease, and infectious disease research
- Amplicon sequencing
- Library preparation and indexing
| Panel types | Predesigned xGen Hyb Panels; Custom xGen Hyb Panels |
| Predesigned panel format | Stocked xGen Hyb Probes; ready to order |
| Custom panel inputs | BED, FASTA, gene symbol, or transcript accession |
| On-target performance | >90% on-target rates (IDT stated claim; results may vary) |
| QC documentation | Standard panels: NGS Functional Test Report; Production panels: ESI-MS per probe available |
8. Large-Scale & Bulk Synthesis
IDT’s large-scale synthesis service produces bulk DNA and RNA oligos from milligram to gram quantities for high-throughput research, commercial assay development, and OEM/GMP-related manufacturing needs. Custom purification, formulation, documentation, and certificates of analysis are available.
- Bulk PCR primers and probes
- NGS adapters and indexed oligos
- siRNA/miRNA and ribozyme production
- Aptamer synthesis
- Commercial assay development
- OEM and GMP-related oligo manufacturing
| Scale range | 10 mg to 10 g final yield |
| Product types | DNA oligos, RNA oligos, aptamers, siRNA/miRNA, NGS adapters, dual-labelled probes |
| DNA length range | 4–100 bases (unmodified) |
| RNA length range | 4–70 bases (unmodified) |
| Purification | Custom — project-dependent |
| QC / documentation | Custom QC, compliance verification, release documentation, certificate of analysis |
| Turnaround | Project dependent |
Use IDT’s free design tools to design your primers, probes, or assays. Standard products can be ordered directly online, while Apical Scientific can assist with customised, modified, or large-scale projects requiring quotation or consultation.
OligoAnalyzer
Analyse Tm, GC content, secondary structures, self-dimers, and BLAST matches. Accepts DNA, RNA, LNA, modified bases, and phosphorothioated sequences.
PrimerQuest
Design PCR, qPCR, and sequencing primers and assays for any species. Customise up to 45 parameters. Add designed assays directly to your IDT cart.
Alt-R CRISPR Design Tools
Includes predesigned gRNA selection, custom gRNA design, design checking, HDR donor design, and CRISPR library design for Cas9 and Cas12a systems.
Resuspension Calculator
Calculate the volume needed to resuspend a dry-shipped oligo to your desired working concentration.
Dilution Calculator
Calculate dilution volumes to go from a stock concentration to your desired working concentration.
xGen Hyb Panel Design Tool
Design custom hybridization capture panels from BED, FASTA, gene symbol, or transcript accession inputs. Save and reorder designs.
| Service | Typical Use Case | Self-Order Online? | Quote Required? | Talk to Apical? |
|---|---|---|---|---|
| Custom DNA Oligos & Primers | PCR, sequencing, mutagenesis primers | ✅ | ⚠️ Large scale or modified | ⚠️ |
| Custom RNA Oligos | CRISPR guides, RNAi, aptamers | ✅ | ⚠️ Complex needs | ⚠️ |
| Modified Oligos | Dye-labelled probes, biotin, phosphorylation | ✅ Catalogue mods | ✅ Off-catalogue mods | ⚠️ |
| qPCR Probes & Assays | PrimeTime probes, multiplex qPCR | ✅ | ⚠️ GMP or unusual formats | ⚠️ |
| Gene Synthesis & Fragments | gBlocks, gene synthesis, cloning templates | ✅ | ⚠️ Complex sequences | ⚠️ |
| CRISPR Alt-R Reagents | Guide RNAs, Cas proteins, HDR donors | ✅ Standard guides | ✅ cGMP/library projects | ⚠️ |
| xGen NGS | Hybridization capture, library prep, adapters | ✅ Predesigned panels | ✅ Custom panels | ✅ |
| Large-Scale Bulk Synthesis | Bulk oligos, commercial/GMP production | ❌ | ✅ All projects | ✅ |